Description
A dual inhibitor of c-Met and VEGFR2; inhibits autophosphorylation of c-Met and phosphorylation of VEGFR2 (IC50s = 14 and 16 nM, respectively); inhibits proliferation in a variety of cancer cell lines; inhibits proliferation of HUVECs stimulated with HGF and VEGF but not bFGF (IC50s = 17, 84, and >1,000 nM); reduces tumor volume dose-dependently in nude mouse xenograft models using MKN45, Hs746T, SNU-5, or EBC-1 cells; increases survival of nude mice implanted with MKN45 cancer cells